How Microdosing LSD Changed My Relationship with Food (And Why It Could Work for You Too)
What if there was a way to suppress your appetite without the harsh side effects of prescription drugs? It sounds too good to be true, but microdosing LSD may offer a surprising solution.
As a psychedelic guide with decades of experience working with sacred medicines, I've seen how deeply microdosing can influence our daily habits and routines.
But this article came about from something much more personal — a day I forgot to eat.
This isn’t a normal occurrence for me. Ever.
I’m not someone who skips meals. In fact, I’m the kind of person who thinks about food regularly, enjoys every bite, and has no problem making time to nourish myself. I’m also deeply committed to eating well — real, whole, nutrient-dense food that supports my body and mind. Cooking is a ritual for me, and I take my health very seriously.
How Did I Just Forget to Eat?!
When I realized it was mid-afternoon and I hadn’t eaten — not because I was busy, stressed, or actively trying to suppress my appetite, but because I simply wasn’t hungry — I took a step back and started paying attention.
The only thing different about my routine that day? I was microdosing LSD.
That sent me down a rabbit hole of research and reflection, leading to this comparison — GLP-1 receptor agonists (like Ozempic and Wegovy) vs. Microdosing LSD.
Two very different substances, yet both influence appetite, reward-seeking behavior, and emotional regulation in fascinating ways.
Quick Disclaimer: I’m Just Someone Paying Attention
I’m not a doctor. I don’t pretend to be. I’m someone who is deeply curious, who experiments, observes, and researches — not in a lab, but in real life. But at the end of the day, what I really am is just someone paying attention — to my mind, my body, and the patterns that shape my behavior, my emotions, and how I move through the world.
GLP-1 Agonists vs. Microdosing LSD: Two Very Different Paths to Appetite Control
Both GLP-1 receptor agonists (like Ozempic and Wegovy) and microdosing LSD influence the way we eat, think, and engage with the world. But they do so in very different ways.
One is a pharmaceutical designed to regulate blood sugar and suppress appetite. The other is a psychedelic taken in tiny doses to enhance creativity, mood, and cognitive flexibility. Yet both seem to change the way we interact with reward-seeking behaviors, particularly around food.
So what’s really happening here?
GLP-1s: The Appetite Killer Designed in a Lab
GLP-1 receptor agonists were originally developed for diabetes treatment, but they quickly gained attention for their impact on weight loss and behavior modification.
These drugs work by:
Delaying gastric emptying, making you feel fuller for longer. (Semaglutide, a GLP-1 receptor agonist, was shown to result in significant weight loss by delaying gastric emptying and increasing satiety.
Interacting with brain reward pathways, dampening cravings for food, alcohol, and other compulsive behaviors. (This study investigates how GLP-1 receptor activation affects brain areas associated with appetite and reward in humans. The findings suggest that GLP-1 receptor agonists can modulate neural responses to food cues, potentially reducing food cravings and aiding in weight management.
Reducing dopamine-driven impulsivity, which can lead to a general decrease in pleasure-seeking activities. GLP-1 affects dopamine activity in brain regions linked to reward and impulsivity.
For many people, GLP-1s quiet the constant mental chatter about food, making eating feel more like a necessity than a source of pleasure. Some report that their emotional connection to food diminishes entirely, leading to unintentional weight loss and, for some, a lack of motivation or joy in everyday activities.
But what about microdosing LSD? If it isn’t designed to affect appetite, why did I experience such a similar effect?
Lysergic Acid Diethylamide (Microdoses)
Unlike GLP-1 agonists, LSD doesn’t directly target hunger hormones or digestion. Yet, many microdosers — including myself — report that they forget to eat, feel less driven by food, or simply aren't as interested in eating as usual.
Here’s why that might be happening:
1. Serotonin & Satiety
LSD acts on the serotonin system, particularly 5-HT2A receptors, which play a key role in mood, perception, and appetite regulation. Many appetite-suppressing drugs (including some antidepressants) also work through their interaction with serotonin.
Since serotonin is known to promote feelings of fullness and satisfaction, microdosing may subtly shift the body’s hunger signals.
2. Increased Focus & Presence
Microdosing often makes people more engaged in the present moment, which might disrupt habitual or emotional eating.
Instead of eating out of boredom or routine, people may become more in tune with true hunger signals. Uses qualitative interviews to explore how microdosers rationalize their behavior within broader health and wellness goals, implying heightened body and self-awareness.)
3. Changes in Reward Sensitivity
LSD influences the dopamine system, but instead of suppressing pleasure (as GLP-1s sometimes do), it reshapes how rewards are perceived.
For example, some microdosers report feeling more drawn to movement, creativity, or social connection rather than food.
In my experience, the appetite suppression from microdosing LSD felt natural—I wasn’t forcing myself to eat less, I just wasn’t thinking about food as much. And when I did eat, it felt more intentional and satisfying rather than habitual.
Side-By-Side Comparison: How GLP-1s & Microdosing LSD Change Behavior
When it comes to changing behavior, GLP-1 agonists and microdosing LSD take completely different approaches.
How They Reduce Appetite
GLP-1 agonists like Ozempic work by directly influencing hunger hormones and digestion. They delay gastric emptying, making you feel fuller for longer, and reduce food intake by regulating how the stomach processes food. This direct intervention results in less of a drive to eat.
Microdosing LSD, on the other hand, doesn’t target hunger hormones directly. Rather than suppressing hunger signals outright, microdosing LSD tends to shift attention away from food — creating a natural disinterest without the forceful suppression seen with GLP-1s.
Effect on Cravings
GLP-1 agonists do more than just curb hunger — they help reduce impulsive behaviors and food cravings. This often leads to a disinterest in overeating, consuming alcohol, or engaging in other compulsive habits. For many, it quiets the constant mental chatter about food, making eating feel less like a source of pleasure.
When it comes to microdosing LSD, the story is a bit different. It doesn’t directly suppress cravings but shifts where our focus lies. Many microdosers report that they simply forget to eat, not because they are trying to skip meals, but because they are so engaged in other activities. This sort of shift isn’t about controlling cravings but about redirecting attention elsewhere.
Impact on Mood & Motivation
Some users of GLP-1 agonists describe a sense of emotional “blunting.” Food and other pleasures seem less rewarding, and overall motivation may decrease. While these drugs may effectively suppress appetite, they can also mute the emotional experience of eating, making it feel like more of a chore than a joy.
In contrast, microdosing LSD tends to have the opposite effect. It enhances curiosity, creativity, and emotional depth. The cognitive and emotional shifts that microdosing brings can make daily experiences feel more engaging. Rather than dulling pleasure, it heightens emotional and intellectual engagement, making life feel more vivid.
Behavioral Shifts
The behavioral changes that GLP-1 agonists bring are often stark. They reduce the priority of food in our lives, but this can also lead to a reduced interest in other pleasure-based activities. For some, it’s not just food that loses its allure — everything from social interactions to hobbies can feel less engaging.
With microdosing LSD, however, the shift in behavior tends to be more focused. It redirects attention toward creative or intellectual pursuits, leading to less focus on food as a side effect rather than a direct suppression.
So… Which One Actually Works Best?
These two substances take very different approaches to behavior change.
GLP-1 agonists are best suited for people who struggle with compulsive eating, weight management, or metabolic disorders and want a biological intervention that requires no active engagement.
Microdosing LSD might be better for those who want a more flexible, cognitively engaging approach — not just to food, but to emotional awareness, creativity, and overall mindset.
While both may reduce appetite, the why and how are completely different. GLP-1s suppress hunger and cravings directly; microdosing LSD seems to shift focus away from food in a way that feels more natural.
I never expected microdosing LSD to change my relationship with food, but it did. Not in a restrictive way, not in a forced way — but in a way that made me more attuned to my body, my hunger, and what actually fuels me beyond just food.
And that’s the real difference.
We'd love to hear from others — have you noticed changes in appetite with microdosing? Let’s talk about it in the comments.
Further Reading
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